Social innovation practices: focus on success factors for crowdfunding

This article explores what are the success factor for interaction with platforms of crowdfunding in Italy. Through a Principal Component Analysis we outline three variables and through a multiple regression analysis we demonstrate that the interaction on crowdfunding is positive correlated with socio-economic propensity and cultural level. The analysis has been conducted on a sample of 316 of projects funded in the Crowdfunding platform Produzioni dal Basso, the first platform born in Italy. We draw on SD logic and relationship marketing to underscore the importance of networks of actors and integration to create a co-creation of value. This view emphasizes the social and economic factors that influence, and are influenced by, crowdfundin

Dark Matter implications of Fermi-LAT measurement of anisotropies in the diffuse gamma-ray background

The detailed origin of the diffuse gamma-ray background is still unknown. However, the contribution of unresolved sources is expected to induce small-scale anisotropies in this emission, which may provide a way to identify and constrain the properties of its contributors. Recent studies have predicted the contributions to the angular power spectrum (APS) from extragalactic and galactic dark matter (DM) annihilation or decay. The Fermi-LAT collaboration reported detection of angular power with a significance larger than $3\sigma$ in the energy range from 1 GeV to 10 GeV on 22 months of data [Ackermann et al. 2012]. For these preliminary results the already published Fermi-LAT APS measurements [Ackermann et al. 2012] are compared to the accurate predictions for DM anisotropies from state-of-the-art cosmological simulations as presented in [Fornasa et al. 2013] to derive constraints on different DM candidates.Comment: 2012 Fermi Symposium proceedings - eConf C12102

Efficient plot-based floristic assessment of tropical forests

The tropical flora remains chronically understudied and the lack of floristic understanding hampers ecological research and its application for large-scale conservation planning. Given scarce resources and the scale of the challenge there is a need to maximize the efficiency of both sampling strategies and sampling units, yet there is little information on the relative efficiency of different approaches to floristic assessment in tropical forests. This paper is the first attempt to address this gap. We repeatedly sampled forests in two regions of Amazonia using the two most widely used plot-based protocols of floristic sampling, and compared their performance in terms of the quantity of floristic knowledge and ecological insight gained scaled to the field effort required. Specifically, the methods are assessed first in terms of the number of person-days required to complete each sample (‘effort’), secondly by the total gain in the quantity of floristic information that each unit of effort provides (‘crude inventory efficiency’), and thirdly in terms of the floristic information gained as a proportion of the target species pool (‘proportional inventory efficiency’). Finally, we compare the methods in terms of their efficiency in identifying different ecological patterns within the data (‘ecological efficiency’) while controlling for effort. There are large and consistent differences in the performance of the two methods. The disparity is maintained even after accounting for regional and site-level variation in forest species richness, tree density and the number of field assistants. We interpret our results in the context of selecting the appropriate method for particular research purposes

Cost-effectiveness of Alzheimer's disease CSF biomarkers and amyloid-PET in early-onset cognitive impairment diagnosis

This study aimed at determining the cost-effectiveness of amyloid-positron emission tomography (PET) compared to Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers (amyloid-?42, total-Tau and phosphorylated-Tau) for the diagnosis of AD in patients with early-onset cognitive impairment. A decision tree model using a national health care perspective was developed to compare the costs and effectiveness associated with Amyloid-PET and AD CSF biomarkers. Available evidence from the literature and primary data from Hospital Clínic de Barcelona were used to inform the model and calculate the efficiency of these diagnostic alternatives. Medical visits and diagnostic procedures were considered and reported in €2020. We calculated the incremental cost-effectiveness ratio to measure the cost per % of correct diagnoses detected and we perform one-way deterministic and probabilistic sensitivity analyses to assess the uncertainty of these results. Compared with AD CSF biomarkers, Amyloid-PET resulted in 7.40% more correctly diagnosed cases of AD, with an incremental total mean cost of €146,854.80 per 100 cases. We found a 50% of probability that Amyloid-PET was cost-effective for a willingness to pay (WTP) of €19,840.39 per correct case detected. Using a WTP of €75,000, the probability that it is cost-effective reached a maximum of 76.9%, thus leading to a conclusion that Amyloid-PET is not a cost-effective technique compared to AD CSF biomarkers, unless the funder is willing to pay a minimum of €19,840.39 to detect one more correct case. Furthermore, obtaining CSF provides simultaneous information on amyloid ? and tau biomarkers and allows other biomarkers to be analyzed at a relatively low cost.© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany

Bases para la educación ciudadana: una propuesta a partir del fortalecimiento de la autonomía como principio de la competencia humana del saber ser para los niños y las niñas de la localidad de Usme

El presente trabajo surge como respuesta a dos intenciones; la primera, por la inquietud e interés de las profesionales aspirantes al titulo de Gerentes Sociales, de aportar a la generación de cambio, con una propuesta de formación dirigida a la población infantil, que lleve a empoderar a los niños y las niñas de la localidad quinta de Usme, para el ejercicio de una ciudadanía activa, que logre afectar de manera positiva sus ámbitos de vida cotidiana y en general el territorio, a través de estrategias pedagógicas centradas en el “saber ser” como competencia humana. La segunda intención, se genera a partir de las expectativas que manifiestan los niños y las niñas frente al deseo de ser reconocidas como “personas grandes”, capaces de contribuir al mejoramiento de sus barrios y de ser parte activa en la solución de los problemas que se presentan frecuentemente a su alrededor. Consideramos además que la formación como Gerentes Sociales, nos invita a favorecer el desarrollo de las comunidades en el contexto local, mediante el diseño e implementación de acciones creativas y novedosas con enfoque integral e integrado, que responda a los cambios globales identificados como la constante y, en ese sentido, a la labor de largo alcance que involucre los actores claves implicados en dichos procesos

Neural Observer Based Hybrid Intelligent Scheme for Activated Sludge Wastewater Treatment

Activated sludge wastewater treatment plants have received considerable attention due to their efficiency to eliminate biodegradable pollution and their robustness to reject disturbances. Different control strategies have been proposed, but most of these techniques need sensors to measure process main variables. This paper presents a discrete-time recurrent high order neural observer (RHONO) to estimate substrate and biomass concentrations in an activated sludge wastewater treatment plant. The RHONO is trained on-line with an extended Kalman filter (EKF)-based algorithm. Then this observer is associated with a hybrid intelligent system based on fuzzy logic to control the substrate/biomass concentration ratio using the external recycle flow rate and the injected oxygen as control actions. The intelligent system and neural observer performance is illustrated via simulations

The AMS-02 RICH Imager Prototype - In-Beam Tests with 20 GeV/c per Nucleon Ions -

A prototype of the AMS Cherenkov imager (RICH) has been tested at CERN by means of a low intensity 20 GeV/c per nucleon ion beam obtained by fragmentation of a primary beam of Pb ions. Data have been collected with a single beam setting, over the range of nuclear charges 2<Z<~45 in various beam conditions and using different radiators. The charge Z and velocity beta resolutions have been measured.Comment: 4 pages, contribution to the ICRC 200

Sfrp1 deficiency makes retinal photoreceptors prone to degeneration

Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells of the retina, the photoreceptors, affecting their integrity. The molecular components contributing to this integrity are however not yet fully understood. Here we have asked whether Secreted Frizzled Related Protein 1 (SFRP1) may be one of such factors. SFRP1 has a context-dependent function as modulator of Wnt signalling or of the proteolytic activity of A Disintegrin And Metalloproteases (ADAM) 10, a main regulator of neural cell-cell communication. We report that in Sfrp1^{-/-} mice, the outer limiting membrane (OLM) is discontinuous and the photoreceptors disorganized and more prone to light-induced damage. Sfrp1 loss significantly enhances the effect of the Rpe6^{Leu450Leu} genetic variant -present in the mouse genetic background- which confers sensitivity to light-induced stress. These alterations worsen with age, affect visual function and are associated to an increased proteolysis of Protocadherin 21 (PCDH21), localized at the photoreceptor outer segment, and N-cadherin, an OLM component. We thus propose that SFRP1 contributes to photoreceptor fitness with a mechanism that involves the maintenance of OLM integrity. These conclusions are discussed in view of the broader implication of SFRP1 in neurodegeneration and aging

Pea PSII-LHCII supercomplexes form pairs by making connections across the stromal gap

In higher plant thylakoids, the heterogeneous distribution of photosynthetic protein complexes is a determinant for the formation of grana, stacks of membrane discs that are densely populated with Photosystem II (PSII) and its light harvesting complex (LHCII). PSII associates with LHCII to form the PSII-LHCII supercomplex, a crucial component for solar energy conversion. Here, we report a biochemical, structural and functional characterization of pairs of PSII-LHCII supercomplexes, which were isolated under physiologically-relevant cation concentrations. Using single-particle cryo-electron microscopy, we determined the three-dimensional structure of paired C2S2M PSII-LHCII supercomplexes at 14 angstrom resolution. The two supercomplexes interact on their stromal sides through a specific overlap between apposing LHCII trimers and via physical connections that span the stromal gap, one of which is likely formed by interactions between the N-terminal loops of two Lhcb4 monomeric LHCII subunits. Fast chlorophyll fluorescence induction analysis showed that paired PSII-LHCII supercomplexes are energetically coupled. Molecular dynamics simulations revealed that additional flexible physical connections may form between the apposing LHCII trimers of paired PSII-LHCII supercomplexes in appressed thylakoid membranes. Our findings provide new insights into how interactions between pairs of PSII-LHCII supercomplexes can link adjacent thylakoids to mediate the stacking of grana membranes

Phenotypic Characteristics and Copy Number Variants in a Cohort of Colombian Patients with VACTERL Association

VACTERL association (OMIM 192350) is a heterogeneous clinical condition characterized by congenital structural defects that include at least 3 of the following features: vertebral abnormalities, anal atresia, heart defects, tracheoesophageal fistula, renal malformations, and limb defects. The nonrandom occurrence of these malformations and some familial cases suggest a possible association with genetic factors such as chromosomal alterations, gene mutations, and inherited syndromes such as Fanconi anemia (FA). In this study, the clinical phenotype and its relationship with the presence of chromosomal abnormalities and FA were evaluated in 18 patients with VACTERL association. For this, a G-banded karyotype, array-comparative genomic hybridization, and chromosomal fragility test for FA were performed. All patients (10 female and 8 male) showed a broad clinical spectrum: 13 (72.2%) had vertebral abnormalities, 8 (44.4%) had anal atresia, 14 (77.8%) had heart defects, 8 (44.4%) had esophageal atresia, 10 (55.6%) had renal abnormalities, and 10 (55.6%) had limb defects. Chromosomal abnormalities and FA were ruled out. In 2 cases, the finding of microalterations, namely del(15)(q11.2) and dup(17)(q12), explained the phenotype; in 8 cases, copy number variations were classified as variants of unknown significance and as not yet described in VACTERL. These variants comprise genes related to important cellular functions and embryonic development